Spider-Man Season 2 introduces the season-long story format for the 1995/6 animated series on double DVD. In the Neogenic Nightmare, Spider-Man battles enemies and himself, as genetic mutation transforms his body beyond recognition.

Chapter#1 - The Insidious Six
Just as Spider-Man starts to lose his powers, Kingpin hires a deadly team of super villains to take him out: Doctor Octopus, Mysterio, the Scorpion, the Rhino, the Shocker and the Chameleon.

Chapter#2 - Battle of the Insidious Six
Things get worse for Spider-Man as he stumbles into a trap and then unknowingly gets caught up in a ferocious battle between Kingpin, the Insidious Six and the Crime Lords.

Chapter#3 - Hydro-Man
Mary Jane is stalked by her old boyfriend, who accidentally turned into Hydro-Man, a villain able to change his body into water. Can Spider-Man put an end to this liquid lust machine?

Chapter#4 - The Mutant Agenda
As his neogenic mutation worsens, Spider-Man approaches Professor Charles Xavier for a cure, but ends up entangled in a dreadful plot to destroy mutants and calls in the help of the X-Men.

Chapter#5 - Mutants' Revenge
Wolverine teams up with Spider-Man to rescue Beast from the clutches of the Hobgoblin and the man behind the evil plot, Dr. Herbert Landon, who mutates into a giant monster.

Chapter#6 - Morbius
Dr. Mariah Crawford develops a cure for Spider-Man’s mutation, but when Dr. Michael Morbius steals and tampers with the untested serum, a pseudo-vampire with superhuman powers is unleashed.

Chapter#7 - Enter the Punisher
As Spider-Man mutates with four extra arms and Morbius continues his bloody rampage, former Marine Frank Castle surfaces in New York as a vigilante, the Punisher, applying his lethal methods to restore order.

Chapter#8 - Duel of the Hunters
It’s a race against time, as Dr. Mariah Crawford enlists the help of Kraven the Hunter to help track down and cure Spider-Man with a new antidote, before the Punisher destroys the newly mutated Man-Spider.

Chapter#9 - Blade, the Vampire Hunter
Spider-Man’s attempts to explain the creation of Morbius as a failed experiment fall on deaf ears, as Marvel anti-hero Blade, the Vampire Hunter, sets off to destroy Morbius and the Neogenic Recombinator.

Chapter#10 - The Immortal Vampire
Blade and Spider-Man have to put their differences to one side if they are to stop Morbius from creating a vampire race and spare his girlfriend, Felicia Hardy, from a similar fate.

Chapter#11 - Tablet of Time
Elderly crime lord Silvermane steals an ancient tablet bearing a formula to restore youth and kidnaps its owner Dr. Connors, leaving Spider-Man in a desperate race for his daily antidote.

Chapter#12 - Ravages of Time
The Tablet of Time transforms Silvermane into a youngster, triggering an almighty battle with the Lizard, Tombstone and Spider-Man.

Chapter#13 - Shriek of the Vulture
Seeking revenge for Norman Osborn trying to hijack his company, Adrian Toomes uses the Tablet of Time to metamorphose into the Vulture and Spider-Man is Norman’s only hope of salvation.

Chapter#14 - The Final Nightmare
The Neogenic Nightmare story concludes in dramatic fashion as Spider-Man, the Vulture, the Scorpion and the Lizard all chase a cure for their mutation, whilst the disappearance of Mary Jane Watson sets up the third Season.